Anna K. Miller

Anna K. Miller

PhD in Genetics and Genome Science, in Progress

Case Western Reserve University

Biography

I’m a PhD Candidate in the Genetics and Genome Sciences Department at Case Western Reserve University. My research focuses on the genetic and environmental aspects of disease, where I use both both traditional and novel statistical and bioinformatic approaches. Outside of lab work, I am passionate about science communication, advocating for graduate students, and science policy.

Interests

  • Genetic Epidemiology
  • Bioinformatics
  • Science Communication
  • Science Advocacy

Education

  • PhD in Genetics and Genome Sciences, in progress

    Case Western Reserve University

  • BA in Biology and Music, 2018

    Albion College

Experience

 
 
 
 
 

Emergency Relief Intern

Broadstreet + COVID-19 data project

Mar 2020 – Jul 2020
 
 
 
 
 

Doctoral Student

Case Western Reserve University

Jul 2018 – Present Ohio
 
 
 
 
 

Summer REU Student

Brandeis University

Jun 2016 – Aug 2016 Massachusetts
 
 
 
 
 

Summer Student Researcher

Henry Ford Hospital

Jun 2015 – Aug 2015 Michigan
 
 
 
 
 

Student Researcher

Albion College

Sep 2014 – May 2018 Michigan

Skills

R/Rstudio

linux/unix

Science Communication

Projects

H. pylori and Human Ancestry predicts gastric cancer

The association of H. pylori and Human Ancestry in predicting severity of gastric cancer

Detecting epistasis using mouse chromosomal substitution strains

Epistasis found using mouse chromosomal substitution strains exposes heritability missed by single loci analyses

APOL1 Genotype in Preeclampsia

The association of Fetal APOL1 Genotype on Maternal Preeclampsia

Recent Publications

See my CV for a full list

A Novel Mapping Strategy Utilizing Mouse Chromosome Substitution Strains Identifies Multiple Epistatic Interactions That Regulate Complex Traits

Non-additive genetic effects are an often underappreciated source of heritability for complex traits, however studies to map and identify the underlying interacting variants remain difficult. Mouse chromosome substitution strains are a powerful approach to discover epistatic interactions given their limited allelic variation and ability to study what in other population structures may be rare allelic combinations. We utilized these strains to map epistatic quantitative trait loci (QTLs) for multiple complex traits and for gene expression. Testing for epistatic interactions revealed multiple large-effect QTLs that were missed using typical single-loci analyses, demonstrating the importance of accounting for epistasis in genetic studies.

Association of preeclampsia with infant APOL1 genotype in African Americans

Polymorphisms in the gene for apolipoprotein L1, known to contribute significant risk for chronic kidney disease, also are associated with preeclampsia in African Americans.

Presentations

See my CV for a full list

Epistatic Regulation of Hematological-related Traits and Gene Expression in Mice Reveals Additional Heritability Missed by Standard GWAS-type Analyses

The genetic contribution of additive versus non-additive (epistatic) effects in the regulation of hematologic and other complex traits …

Awards & Honors

See my CV for a full list

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