H. pylori and Human Ancestry predicts gastric cancer

Chronic infection with Helicobacter pylori infection is necessary but not sufficient to initiate development of intestinal-type gastric adenocarcinoma. It is unclear what additional factors tip the scale from commensal bacteria towards a pathogen that facilitates development of gastric cancer. Genetic variants in both the pathogen and host have been implicated, but neither alone explains a substantial portion of disease risk. We study the association of H. pylori and Human ancestry to detect factors that drive disease through the interaction of pathogen and host.

Anna K. Miller
Anna K. Miller
PhD in Genetics and Genome Science, in Progress

My research interests include genetic epidemiology and epistasis matter.